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KMID : 0380020140290050385
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Korean Journal of Biotechnology and Bioengineering
2014 Volume.29 No. 5 p.385 ~ p.391
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Effect of Storage Temperature on the Dispersion Stability of O/W Nano-emulsions
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Lee Ye-Eun
Yoo In-Sang
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Abstract
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In this study, the emulsion dispersion stability of optimizing storage temperature was investigated. The system was based on oil/water (O/W) emulsions. In order to evaluate the stability, mean diameter of droplet was measured as a function of temperature with various mixed hydrophilic lipophilic balance (HLB). In addition, the correlations between phase inversion temperature (PIT) and the optimum storage temperature were probed. In this system, majority of the smallest droplet was shown at temperature of 20℃ below PIT. Whether the temperature was increased or decreased from the optimum, size of the droplet increased. According to the mixed HLB, the particle size and optimum storage temperature were also affected. As the concentrations of surfactant were increased, the size of particle decreased with lower optimum temperature for storage. If the surfactant (4 wt%) were mixed with HLB, the optimum storage temperature was 21℃ for maintaining the size of smallest droplet at 108.3 nm in diameter. At above optimum condition, increased size of particle was observed approximately 4 % increases from 108.2 nm to 112.3 nm after 600 hours. The size of particle in emulsion was maintained stably without any considerable effect of Ostwald ripening phenomena at the optimum storage temperature with low polydispersity index.
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KEYWORD
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O/W nano-emulsion, Mixed HLB, PIT, Optimum storage temperature, Polydispersity
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